by Peter Mac researchers have made a groundbreaking discovery that sheds light on the long-standing enigma of how cells perform distinct functions, paving the way for potential advancements in cancer treatments. This research, published in Nature Genetics, offers new insights into the intricacies of cell behavior and the implications are far-reaching.
Professor Mark Dawson, a physician-scientist and Associate Director of Research at Peter Mac, expressed his excitement about the newfound knowledge, stating that we now have a better understanding of how a cell’s fate is determined. He explained that the way a cell functions is the result of ‘transcription factors’ that scan our DNA and decide which genes should be activated and to what extent.
Until now, it was unclear how these transcription factors selected the appropriate machinery for a gene to be expressed. This question has puzzled scientists for decades, and the recent discovery provides us with fundamental knowledge on the workings of life.
The study revealed that transcription factors choose a specific set of components to drive gene expression, enabling the creation of the desired cellular response – be it controlling energy consumption, launching an immune response, or performing other essential functions. Professor Dawson likened this process to the manufacturing of different types of vehicles, explaining that just as cars are designed to serve various purposes, gene expression is determined by the components recruited by transcription factors.
An F1 racing car, for instance, is designed for high-speed performance, while a family people mover is built for transporting large groups, and a tractor is the workhorse. Similarly, gene expression is influenced by the components recruited by transcription factors, which can determine whether genes need to respond quickly or operate steadily to carry out their functions. This discovery is crucial in our quest for better treatments for various diseases, including cancer.
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1.Source: Coherent Market Insights, Public sources, Desk research
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