by A groundbreaking study conducted by a team of researchers at the University of California, Irvine (UCI) has shed light on the potential of utilizing the circadian clock to boost the effectiveness of checkpoint inhibitor cancer therapy. Checkpoint inhibitors function by obstructing the binding of specific proteins to tumor cells, thereby enabling the immune system’s T cells to eliminate the tumor.
The team’s findings, published in the prestigious journal Nature Immunology, offer valuable insights into the intricate connection between the circadian clock, immune regulation, and Cancer Therapy. The study revealed that optimizing the timing of therapeutic intervention based on an individual’s unique circadian patterns presents a promising new avenue for cancer prevention and treatment.
Selma Masri, UC Irvine associate professor of biological chemistry and the study’s corresponding author, explained, “Disruption of the internal biological pacemaker, which is a common occurrence in modern society, may contribute to the rising incidence of various cancer types. Our research demonstrates that maintaining proper regulation of circadian rhythms is crucial for suppressing inflammation and supporting optimal immune function. Understanding the mechanisms behind circadian disruption and its role in disease progression could lead to behavioral modifications to minimize cancer risk.”
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1. Source: Coherent Market Insights, Public sources, Desk research
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