by What is Exelon?
It belongs to a class of medications known as cholinesterase inhibitors. These drugs work by increasing levels of a chemical messenger in the brain called acetylcholine, which helps with communication between brain cells. Exelon is available in both oral capsule and transdermal patch formulations under the brand names Exelon and Exelon Patch.
How Does Exelon Work?
Exelon works by inhibiting the breakdown of acetylcholine in the brain by blocking the enzymes acetylcholinesterase and butyrylcholinesterase. These enzymes are known to degrade acetylcholine, which is an important neurotransmitter involved in memory and thinking. By inhibiting these enzymes, Exelon increases the level of acetylcholine available to bind to receptors in the brain. This helps improve communication between neurons and may temporarily improve symptoms of dementia such as memory loss, problem solving abilities, and attention in people with Alzheimer’s disease.
Approved Uses and Dosing
Rivastigmine is approved by the U.S Food and Drug Administration (FDA) for the treatment of mild to moderate dementia associated with Alzheimer’s disease. It comes in capsule and transdermal patch formulations. The capsule is typically taken twice per day and dosing starts at 1.5 mg twice daily and can be increased up to 6 mg twice daily as tolerated by the patient. The transdermal patch releases Exelon through the skin continuously over 24 hours. It is changed once daily and dosing starts at 4.6 mg/24 hours and can be increased up to 9.5 mg/24 hours.
Efficacy and Potential Benefits
Several clinical trials have demonstrated the efficacy of Exelon in improving symptoms of dementia in people with mild to moderate Alzheimer’s disease. In one 24-week study of 259 patients, those treated with Exelon capsules scored significantly better on measures of cognitive function, global function, and behavioral symptoms compared to placebo. Other potential benefits seen with Exelon treatment include reduced caregiver burden by temporarily improving the ability of patients to carry out daily tasks. By slowing cognitive decline, Exelon may also help delay the need for institutional long-term care.
otential Side Effects
While generally well tolerated at appropriate doses, Exelon can cause some common side effects like nausea, vomiting, diarrhea, loss of appetite and weight loss during initial dose titration periods. Other potential side effects include dizziness, headache, increased frequency of urination, muscle cramps, fatigue and involuntary muscle movements. Rivastigmine may also cause application site reactions in some users of the transdermal patch. Rare but serious side effects include changes in heart rate or blood pressure, difficulty breathing, fainting, seizures and skin reactions like rash or hives.
Drug Interactions and Precautions
Due to its effects on acetylcholine levels in the brain and body, Exelon can potentially interact with other medications that also affect cholinergic systems. These include other cholinesterase inhibitors, medications for Parkinson’s disease, certain antibiotics, muscle relaxants and anesthetic gases. People with active or recent history of peptic ulcers, asthma or urinary obstruction should also use Exelon cautiously. As with any prescription drug, patients should discuss all medications and supplements with their doctor before starting treatment with Exelon.
Alternative Treatment Options
Besides Rivastigmine, there are two other FDA-approved cholinesterase inhibitor drugs used to treat mild to moderate Alzheimer’s disease – donepezil (Aricept) and galantamine (Razadyne). Memantine (Namenda), a N-methyl-D-aspartate receptor antagonist, is another prescription medication approved as a treatment option either alone or combined with a cholinesterase inhibitor. Non-drug lifestyle interventions including cognitive stimulation therapies, physical activity, social engagement and a healthy diet may also provide some symptomatic benefits, though drugs are still the first-line treatment. Further research continues into disease-modifying therapies that can slow or stop progression of Alzheimer’s pathology.
Rivastigmine is an important prescription drug used to help manage cognitive, behavioral and functional symptoms of Alzheimer’s disease. As a cholinesterase inhibitor, it works by increasing levels of acetylcholine in the brain. Clinical evidence supports its efficacy in temporarily improving symptoms of dementia, especially in mild to moderate cases. While generally well tolerated, Exelon requires careful medical management and monitoring due to its side effects and drug interactions. It provides an approved treatment option along with other medications, therapies and lifestyle factors for managing cognition in Alzheimer’s patients.
*Note:
1.Source: Coherent Market Insights, Public sources, Desk research
2.We have leveraged AI tools to mine information and compile it
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